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1982
Dr. Stanley B. Prusiner, neurologist, reported the discovery of an infectious agent that linked certain animal and human diseases. His lab identified a tiny molecule in the membrane of cells that he called a proteinaceous infected particle, or prion for short. In 1996 it is suspected that this is the agent involved in the bovine mad-cow disease and the rare human Creutzfeldt-Jacob disease.
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1985
Dr. Richard F. Marsh (d.1997 at 58) observed that the disease mink spongiform encephalopathy was very similar to bovine spongiform encephalopathy (mad cow disease), and that food supplement made from cattle and fed to the minks was probably the route of disease transmission.
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1986
Mad Cow Disease, bovine spongiform encephalopathy (BSE), was first confirmed in Britain.
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1996 Mar 20
The British government said that a rare brain disease that had killed 10 people was probably linked to so-called "mad cow disease."
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1996 Mar 26
Amid public fears of mad cow disease, British farmers demanded their government order the destruction of old cattle, but Prime Minister John Major refused, and blamed the crisis on his political opponents.
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1996 Mar 27
The European Union imposed a global ban on British beef and beef products due to concerns over mad cow disease.
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1996 Jun 5
The European Commission decided to ease the ban on British exports over mad cow disease.
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1996 Jun 19
The European Union approved a British plan for wiping out "mad cow" disease.
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1996 Jun 21
European leaders agreed to gradually lift a global ban on British beef exports imposed nearly three months earlier following a scare over "mad cow" disease.
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1996 Sep 26
The New England Journal of Medicine reported new research that would provide a simple test for mad cow disease based on a protein specific to the disease.
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1996
Britain banned exports of meat and bone meal due to possible risks of "mad-cow" disease.
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1997 Apr 28
It was reported that a type of Mad Cow Disease was killing deer and elk in the Fort Collins region of Colorado and Wyoming. The "spongiform encephalopathies" riddled the brain with holes and it was wondered if the disease might be transmitted to humans as the fatal Creutzfeldt-Jacob disease.
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1997 Jun 3
The United States banned most slaughtered-animal parts from livestock feed because of concerns over "mad cow disease."
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1997
A North American ban on cattle feed that included bovine brain and spinal tissue went into effect to prevent the spread of mad cow disease, bovine spongiform encephalopathy.
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1997
Prionics AG of Switzerland developed the 1st efficient test for mad cow disease, bovine spongiform encephalopathy.
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1998 Jan 20
In Texas jury selection in the multi-million-dollar lawsuit trial of Oprah Winfrey began. She was being sued by Texas cattlemen for remarks on her Apr 16, 1996 show about mad cow disease. The case was initially a test of the state’s 1995 "veggie libel" law that protected perishable food products from false and defamatory statements, but was ruled to proceed as a common-law business defamation case. Winfrey won the case on Feb 26.
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1998 Feb 26
A jury in Amarillo, Texas, rejected an $11 million lawsuit brought by Texas cattlemen who blamed Oprah Winfrey's talk show for a price fall after a segment on food safety that included a discussion about mad-cow disease.
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1998 Aug 8
A riot broke out in Reno, Nv., during the annual "Hot Autumn Nights" festival. There was some property damage and a few minor injuries. 130 people were arrested.
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1998 Nov 23
The European Union lifted a worldwide export ban on British beef. The ban was imposed after experts announced a possible link between "mad cow" disease and a fatal disease in humans.
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1999 Jul 14
The EU agreed to resume British beef exports on Aug 1, ending a 3-year ban due to mad cow disease.
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1999 Aug 1
The EU cleared British beef for export. A ban had followed the 1996 mad cow crises.
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1999 Oct 29
An EU Commission ruled that British beef was safe to eat despite French arguments for a ban to guard against mad cow disease.
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2000 Nov 22
In Spain the government reported its 1st case of mad cow disease.
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2000 Nov 24
Germany and the Portuguese Azores Islands recorded new cases of mad cow disease. Main land Portugal has reported 467 cases since 1990.
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2000 Dec 4
European Union farm ministers approved a six-month ban on animal products in fodder, part of an extraordinary plan to stem growing panic over mad cow disease.
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2001 Jan 8
It was reported that Britain was culling 20-30 thousand older cows per week in the mad cow crises and that it would take 3 years to catch up with the backlog for rendering their remains to powder.
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2001 Jan 31
Germany announced plans to destroy 400,000 cattle due to the mad cow crises.
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2001 Feb 3
Mexico followed Canada and the US in a ban on beef from Brazil due to fears of mad cow disease.
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2001 Feb 28
Officials in Northern Ireland confirmed hoof-and-mouth disease in sheep imported from England. 8 more cases were confirmed in England and Wales.
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2001 Mar 21
In Vermont a flock of 234 sheep were seized by federal agents over fears of infection with a version of mad cow disease. The sheep had originated in Belgium in 1996.
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2001 Aug
Gary Padgham (50), an elk hunter from Bozeman, Montana, died in Monterey, Ca., with symptoms similar to mad cow disease. Seattle doctors had diagnosed him with Creutzfeldt-Jacob disease (CJD).
Links: Mad Cow, Montana     Click to see the source(s) for this event 
 
2001 Sep 10
In Japan the government reported that a dairy cow had tested positive for mad-cow disease. It was the 1st instance of the disease in Asian animals.
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2001 Nov 22
Japan confirmed a 2nd mad cow case and planned to slaughter and incinerate 5,100 cows.
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2002 Feb 5
In Italy the health ministry confirmed the country's 1st case of mad cow disease.
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2002 May 11
In Japan a cow tested positive for mad cow disease for the 1st time since last fall.
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2002 Oct 21
Scientists reported a new immunoassay for mad cow disease that takes about a year for results.
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2003 May 20
Canadian agriculture officials said that it took 15 weeks -- from Jan. 31 to May 16 -- before a battery of tests ordered on a sickly, underweight cow that had been deemed unfit for human consumption proved it had mad cow disease. In 2004 investigators identified 68 British cattle as the probable source of Canada's mad cow cases.
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2003 May 20
The United States banned all beef imports from Canada after a lone case of mad cow disease was discovered in the heart of Canada's cattle country.
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2003 Sep 29
In Japan a 23-month-old bull tested positive for new strain of mad cow disease. A quarantine of 604 cows followed to prevent the spread of the disease.
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2003 Dec 17
The British government announced the first reported case of a person dying from the human form of mad cow disease after a blood transfusion from an infected donor.
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2003 Dec 23
A cow, slaughtered in Washington state on Dec 9, was reported to have tested positive for mad cow disease. The $2.6 billion beef export industry was hit as 7 nations quickly suspended imports of U.S. beef: Japan, South Korea, Singapore, Thailand, Malaysia, Taiwan and Australia. The Holstein infected with mad cow disease was imported into the United States from Canada about two years ago.
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2004 Feb 17
A new study reported that 2 cows in Italy had been found with a new form of mad cow disease, bovine amyloidotic spongiform encephalopathy (BASE).
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2004 Feb 22
Japanese authorities confirmed the nation's 10th case of mad cow disease since the first sick animal was discovered in September 2001.
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2004 Sep 10
Japan confirmed a 12th case of mad cow disease.
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2004 Oct 21
French health officials announced that a donor whose blood was used to transfuse 10 people and to manufacture medicines has been identified as France's eighth known victim of the human equivalent of mad cow disease.
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2004 Nov 18
The US government reported a possible case of mad cow disease.
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2004 Dec 30
Officials said Canada has found what may be a second case of mad cow disease, just a day after the US said it planned to reopen its border to Canadian beef.
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2005 Jan 2
Canada confirmed that a 2nd case of mad cow disease has been discovered, just days after the United States said it planned to reopen its border to Canadian beef.
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2005 Feb 4
Japan confirmed its 1st human death from mad-cow disease. It was suspected that the man died as a result of beef he consumed in England around 1989.
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2005 Jun 11
US officials said a cow had tested positive for mad cow disease in November, opening the door to possible changes in testing procedures in the US beef industry. The cow was later identified as being calved in Texas in 1993.
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2005 Jun 21
Austria’s Health Minister Maria Rauch-Kallat announced a cow in an alpine farm Austria has been found to be infected with mad cow disease.
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2005 Jun 24
US Agriculture officials said a 2nd case of mad cow disease was confirmed in a cow from Texas. This case of the disease, as well as one from Alabama in 2006, was later reported as atypical.

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2005 Jun 25
Taiwan reimposed a ban on imports of American beef after the US confirmed its second case of mad cow disease.
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2005 Nov 21
The US federal Centers for Disease Control said a man from Great Britain has been diagnosed with the human form of mad cow disease, the 2nd documented US case of the illness.
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2005 Dec 12
Japan gave the final go-ahead to resume imports of some US beef after a two-year ban due to fears of mad cow disease, averting a potential trade war between the close political allies.
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2006 Jan 13
South Korea agreed to resume imports of some American beef, banned two years ago over fears of mad cow disease. The US government pressed South Korea to accept all US beef imports.
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2006 Jan 20
Japan halted imports of US beef just a month after lifting a ban, following the discovery of spinal material in a shipment that should have been removed due to the risk of mad cow disease.
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2006 Jan 23
Canadian officials said a cow from Alberta had tested positive for mad cow disease.
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2006 Feb 9
Japanese officials said 45 cows at a farm in northern Japan were suspected of having mad cow disease and will be destroyed.
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2006 Mar 3
An EU executive said Sweden's first case of mad cow disease has been confirmed by the European Union's central laboratory.
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